刘世轩，教授，博士生导师。2004年本科毕业于西北农林科技大学生命科学学院，2010年博士毕业于中国科学院生物物理研究所。后前往圣路易斯华盛顿大学从事博士后等研究工作。2022年回国，入选中国药科大学兴药领军学者。迄今以第一作者在Science, Science Advances，Nature Protocols, Nature Communications, PNAS 等国际顶尖杂志上发表了多篇学术论文。主要研究方向包括凝血等领域重要药物作用靶点的膜蛋白结构机理研究(x-ray和冷冻电镜)，药物筛选与设计，蛋白质工程及相应方法与工具的开发。
代表性论文：
1. Shixuan Liu, Shuang Li, Andrzej M. Krezel, Weikai Li*, Stabilization and structure determination of integral membrane proteins by termini restraining, Nature Protocols, 2022, 17: 540-545.
2. Shixuan Liu, Shuang Li, Guomin Shen, Narayanasami Sukumar, Andrzej M. Krezel, Weikai Li*, Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation, Science, 2021, 371(6524): 43+(1-10).
3. Shixuan Liu, Shuang Li, Yihu Yang, Weikai Li*, Termini restraining of small membrane proteins enables structure determination at near-atomic resolution, Science Advances, 2020, 6(51): 1-12.
4. Shuang Li, Shixuan Liu, Xiaoran Roger Liu, Mengru Mira Zhang, Weikai Li*, Competitive tight-binding inhibition of VKORC1 underlies warfarin dosage variation and antidotal efficacy, Blood Advances, 2020, 4(10): 2202-2212.
5. Shuang Li, Shixuan Liu, Yihu Yang, Weikai Li*, Characterization of Warfarin Inhibition Kinetics Requires Stabilization of Intramembrane Vitamin K Epoxide Reductases, Journal of Molecular Biology, 2020, 432(18): 5197-5208.
6. Shixuan Liu#, Wei Cheng#, Ronald FowleGrider, Guomin Shen, Weikai Li*, Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer, Nature Communications, 2014, 5: 1-9. (# Co-first author)
7. Shixuan Liu, Maxim Balasov, Hongfei Wang, Lijie Wu, Igor N. Chesnokov*, Yingfang Liu*, Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB, Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(18): 7373-7378.
